NICODOM Kidney Stone
Analysis Kit
For Kidney Stone Analysis by
FTIR NICODOM Ltd. offers two different products:
NICODOM Kidney Stone Infrared Spectra Library - 1668 FTIR spectra of Kidney Stones, compatible with most
spectroscopic software packages. For description of the NICODOM Kidney Stone
FTIR Library click here.
NICODOM Kidney Stone Analysis Kit - combination of qualitative and quantitative analysis,
kidney stone guide, only compatible with Thermo OMNIC SEARCH software (Nicolet
FTIR spectrometers)
The NICODOM Kidney Stones
Analysis software package has been created by spectroscopists and medical
doctors to allow semiautomated analysis of kidney stones using Thermo (Nicolet)
FTIR spectrometers with OMNIC software. This software will not work without
OMNIC software. OMNIC software can be purchased thru the Thermo representative
in you country, we cannot deliver the OMNIC software.
The NICODOM Kidney Stone Analysis Kit consists of three
parts.
NICODOM KIDNEY STONE LIBRARY - BASIC
This approach is not new and allows analyzing
samples by less qualified personal. The library of about 800 spectra allows
analysis with +- 10% accuracy (error of 10-15 % is without clinical relevance).
This accuracy varies for different mixtures, best results (error less than 5%)
were reached for major components in concentration range of 30-70%. As far as
no peak shifts were observed comparing spectra of pure components with those of
real mixtures, spectra of conceivable mixtures were created by combination of
pure components. On the other hand, pure kidney stones must have been used,
because their infrared spectra differ from those of mineralogically or
chemically pure substances. For example each real urinary concrement contains a
low content of unknown "matrix". "Matrix" contains mostly
organic components, that is why the SEARCH operation in the region of 2900 -
3100 cm-1 can fail and thus searching in finger print region is recommended.
NICODOM KIDNEY STONE ANALYSIS
A combination of qualitative and quantitative
analysis is used. The content of a component is calculated from the match
values of search result using a coded library of over 18.000 spectra and
special algorithms. This type of analysis rejects other than kidney stones
spectra, corrects or rejects distorted spectra and has improved accuracy.
Spectra of common artifacts, drug and rare stones are included. All results
include reliability factor of the analysis and can be stored with the spectrum.
Visual comparison of the sample spectrum with the theoretical spectrum is also
an important feature.
212 spectra files of real stones (found in human kidney) and 23
spectra files of major pure components are also included as examples to
demonstrate capabilities of the software.
Examples of result windows
(advanced analysis):
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NICODOM
KIDNEY STONE GUIDE
This
part of the kit includes additional information about the kidney stones
components. Interpreted infrared spectra of stones and pure chemicals are
included. Its Raman spectrum, picture of the stone, other methods of chemical
analysis (qualitative, semiquantitative, quantitative), causes and occurrence
of the component, optical properties, table of peaks, structural formula and
other information is also included.
This
guide also gives to the chemists a brief information about medical aspects of
kidney stone analysis, like diagnosis and therapy.
You can choose what information
you want to display for the investigated stone (Whewellite as example):
Each type of information
displays in a separate window
All information about one stone
displayed as "cascade"
SAMPLING METHOD
The spectra were collected and software has been
tested with KBr pellets transmission spectra. If your sampling method is ATR or
diffuse reflectance, the NICODOM Kidney Stone Analysis Kit will still deliver acceptable
results under following conditions:
- Your spectra should be collected with quality
comparable to transmission spectra (noise, spectral range, sample thickness, humidity…)
- Your spectra should be corrected (baseline correction, ATR correction, Kubelka-Munk
correction, those corrections are usually part of your software)
Please refer to ATR or diffuse reflectance theory
to understand limitations of those sampling methods.
Note that today most laboratories use ATR or
diffuse reflectance sampling technique and they use NICODOM Kidney Stone Analysis Kit without problems.
MORE INFORMATION
For more information also view the article as pdf
file: http://www.ftir.cz/Kidclan2.pdf
Download
promo material: http://www.ftir.cz/kid2sheet.pdf
Download Kidney Stone Analysis Kit Users Guide: http://www.ir-spectra.com/download/NICODOM_KS_Kit_Guide.pdf
This software package requires Thermo (Nicolet) OMNICTM
software being installed on your computer.
To download the list of spectra from this library, to
download a free demo library compatible with your software, to check the format
compatibility as well as for pricelist, ordering info and information about all
NICODOM IR/NIR Libraries and other NICODOM products please visit our webpage.
NICODOM Kidney Stone
Analysis Kit
Copyright © NICODOM 2006
NICODOM Ltd., Hlavni 2727,
CZ-14100 Praha 4, Czech Republic, EU
Tel: +420-281914970, Fax:
+420-281914971
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